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Genetic and phenotypic variability can quietly undermine otherwise valuable mouse studies—confounding results, reducing reproducibility, and triggering costly delays when reviewers require confirmation on a well-defined congenic background. This paper explains why genetic background matters, how traditional congenic breeding can take years and increase risk, and how marker-assisted “speed congenics” using SNP testing can achieve equivalent background homogeneity in roughly half the time while improving efficiency, reducing animal use, and strengthening confidence in experimental outcomes.
