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Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin c deficient mice

Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin c deficient mice.
 
 J. Cha, M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
 
 
Our main objective was to determine the effect of ascorbate supplementation in mice unable to synthesize ascorbic acid (gulo KO) when challenged with murine B16FO cancer cells.
 

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